Research Papers

Our approach is rooted in continuous learning and transparency. We believe it's important to share the research that informs our hands-on, non-invasive treatment approach.

The studies below explore the causes and impact of soft tissue fibrosis and adhesion — key contributors to chronic pain. While many focus on surgical solutions, we apply these insights to guide our non-surgical care.

Please note: These papers are clinical in nature and may be technical for general readers.

Chronic conditions, diagnosis & treatment

• Posterior Hip and Buttock Pain: Relation to Deep Gluteal Syndrome | biomedres.us
• Sciatic Nerve Entrapment due to Fibrous Adhesion in the Deep Gluteal Space- Proposed Clinical Diagnostic Criteria and Therapy Using Manual Adhesion Release® | clinmedjournals.org
• Deep gluteal syndrome: anatomy, imaging, and management of sciatic nerve entrapments in the subgluteal space | pubmed.ncbi.nlm.nih.gov
• The Endoscopic Treatment of Sciatic Nerve Entrapment-Deep Gluteal Syndrome | pubmed.ncbi.nlm.nih.gov
• Stretching of roots contributes to the pathophysiology of radiculopathies | pubmed.ncbi.nlm.nih.gov
• Anatomical etiology of “pseudo-sciatica” from superior cluneal nerve entrapment: a laboratory investigation | doi.org
• Anatomical study of superior cluneal nerve entrapment | pubmed.ncbi.nlm.nih.gov
• Association between intermittent low-back pain and superior cluneal nerve entrapment neuropathy | pubmed.ncbi.nlm.nih.gov
• Fibrous adhesive entrapment of lumbosacral nerve roots as a cause of sciatica | pubmed.ncbi.nlm.nih.gov
• Increased Fibrogenic Gene Expression in Multifidus Muscles of Patients With Chronic Versus Acute Lumbar Spine Pathology | pubmed.ncbi.nlm.nih.gov
• Manual therapy as an effective treatment for fibrosis in a rat model of upper extremity overuse injury | pubmed.ncbi.nlm.nih.gov
• Reduced thoracolumbar fascia shear strain in human chronic low back pain | ncbi.nlm.nih.gov

Shockwave for musculoskeletal disorders

• Extracorporeal shockwave therapy in musculoskeletal disorders | josr-online.biomedcentral.com
• Extracorporeal shock wave therapy mechanisms in musculoskeletal regenerative medicine | journal-cot.com
• Radial extracorporeal shockwave promotes subchondral bone stem/progenitor cell selfrenewal by activating YAP/TAZ and facilitates cartilage repair in vivo | stemcellres.biomedcentral.com
• Enhanced Spinal Therapy: Extracorporeal Shock Wave Therapy for the Spine | ncbi.nlm.nih.gov
• Low energy extracorporeal shock wave therapy combined with low tension traction can better reshape the microenvironment in degenerated intervertebral disc regeneration and repair | pubmed.ncbi.nlm.nih.gov
• Biological response of extracorporeal shock wave therapy to tendinopathy in vivo | ncbi.nlm.nih.gov
• Impact of radial extracorporeal shock wave therapy in post-laminectomy epidural fibrosis in a rat model | ncbi.nlm.nih.gov
• Shock wave as biological therapeutic tool: From mechanical stimulation to recovery and healing, through mechanotransduction | pubmed.ncbi.nlm.nih.gov
• The effect of extracorporeal shock wave on joint capsule fibrosis in rats with knee extension contracture: a preliminary study | tandfonline.com

Ageing, degeneration & fibrosis/adhesion

• Increased Wnt Signaling During Aging Alters Muscle Stem Cell Fate and Increases Fibrosis | science.sciencemag.org
• Structural and Functional Changes in the Coupling of Fascial Tissue, Skeletal Muscle, and Nerves During Aging | ncbi.nlm.nih.gov
• Alterations in quadriceps muscle cellular and molecular properties in adults with moderate knee osteoarthritis | ncbi.nlm.nih.gov
• The Role of Changes in Extracellular Matrix of Cartilage in the Presence of Inflammation on the Pathology of Osteoarthritis | ncbi.nlm.nih.gov
• The association of cervical sagittal alignment with adjacent segment degeneration | link.springer.com
• Regulation of cellular senescence by extracellular matrix during chronic fibrotic diseases | ncbi.nlm.nih.gov
• Senescent cells: an emerging target for diseases of ageing | ncbi.nlm.nih.gov
• Roles of Articular Cartilage Aging and Chondrocyte Senescence in the Pathogenesis of Osteoarthritis | ncbi.nlm.nih.gov

Adhesion / Fibrosis development

• Pathophysiological Tissue Changes Associated With Repetitive Movement: A Review of the Evidence | ncbi.nlm.nih.gov
• Hypoxia-generated superoxide induces the development of the adhesion phenotype | ncbi.nlm.nih.gov
• Modulation of fibroblast proliferation by oxygen free radicals | pubmed.ncbi.nlm.nih.gov
• Low Oxygen Stimulates Proliferation of Fibroblasts Seeded as Single Cells | doi.org
• Tensile Mechanical Properties of Three-Dimensional Type I Collagen Extracellular Matrices With Varied Microstructure | pubmed.ncbi.nlm.nih.gov

Metabolic / Immune System

• Gut-spine axis: a possible correlation between gut microbiota and spinal degenerative diseases | ncbi.nlm.nih.gov
• Gut microbiota and intervertebral disc degeneration: a bidirectional two-sample Mendelian randomization study | pubmed.ncbi.nlm.nih.gov
• Gut-disc axis: A cause of intervertebral disc degeneration and low back pain? | pubmed.ncbi.nlm.nih.gov
• Progressive multifocal fibrosing neuropathy: description of a novel disease | actaneurocomms.biomedcentral.com